The speaker is discussing their personal approach to maintaining health and longevity, emphasizing diet, exercise, and supplementation. They mention their busy schedule and the difficulty of maintaining a regular eating pattern, resorting to intermittent fasting, often eating late into the night. They also talk about a study suggesting that when to eat is as important as what to eat for longevity.
The speaker discusses their research in their lab, where they've been studying the effects of diet and exercise on health and longevity for the past 20 years. They discuss the discovery of a set of genes called sirtuins that control aging in organisms. They found that these genes can extend the lifespan of yeast cells, mice, and worms.
To mimic this process in humans, they are developing molecules that can boost the body's levels of a molecule called NAD, which is necessary for the sirtuins to work. They mention two such molecules: NMN and resveratrol. They also discuss another molecule, metformin, which they take for its potential to extend lifespan and protect against diseases of aging.
In terms of personal supplementation, the speaker takes a gram of NMN and a half-gram of resveratrol every morning, and a gram of metformin at night. They also mention trying to maintain a low-carb, low-sugar diet, avoiding meat due to its potential to activate harmful pathways in the body, and practicing temperature stress on their body through saunas and cryotherapy.
The speaker concludes by emphasizing the importance of activating the body's defenses against aging, rather than focusing on simply avoiding the causes of aging as traditionally understood. They suggest that the key is to maintain a balance, limiting calories, carbohydrates, and protein while increasing beneficial molecules, in order to thrive during adversity and live a long, healthy life.
1. The speaker is involved in running a lab that studies the processes that diet and exercise do for us, aiming to keep us healthy. [Source: Document(page_content="00:00:00.00: as me and he's about three and a half...")]
2. The speaker engages in intermittent fasting and tries to keep a healthy weight. [Source: Document(page_content="00:00:00.00: as me and he's about three and a half...")]
3. The speaker believes that the timing of eating is more important than the food itself for longevity. [Source: Document(page_content="00:00:33.00: in mice that it's not what you eat it's...")]
4. The speaker's lab has been studying the effects of diet and exercise for the last 20 years. [Source: Document(page_content="00:00:56.55: they've been studying my lab for the last 20...")]
5. The speaker is researching molecules that could mimic the effects of intermittent fasting and diet, believing they could be as effective or even more so than intermittent fasting. [Source: Document(page_content="00:01:17.49: resveratrol from red wine that molecule...")]
6. The speaker is currently researching molecules that could potentially extend the lifespan of animals, including mice. [Source: Document(page_content="00:02:22.45: even further than it could with either...")]
7. The speaker has discovered a molecule called NMN that can boost the body's levels of a molecule called NAD, which is crucial for the functioning of Sirtuin genes. [Source: Document(page_content="00:03:05.80: Lenny gaurantee and a team of us at...")]
8. The speaker takes a gram of NMN every morning, along with resveratrol and metformin. [Source: Document(page_content="00:05:22.17: I take a gram of any men in...")]
9. The speaker believes that the FDA doesn't allow the use of metformin for aging because aging isn't officially considered a disease yet. [Source: Document(page_content="00:06:53.38: aging because aging isn't a disease yet...")]
10. The speaker follows a diet that includes skipping meals, avoiding sugars and carbs, running once a week, and doing workouts on the weekends. [Source: Document(page_content="00:09:34.78: generally generally I eat normally do...")]
11. The speaker believes that activating the body's defenses against aging is the key to longevity. [Source: Document(page_content="00:11:35.12: finding is that their molecules in...")]
12. The speaker believes that the molecules found in plants, such as resveratrol, make plants stronger during times of stress. [Source: Document(page_content="00:11:44.63: hormesis a little bit of stress is good for...")]
13. The speaker believes that consuming branch chain amino acids, a natural part of the human body, could potentially shorten lifespan. [Source: Document(page_content="00:13:54.12: like taking testosterone it will give...")]
14. The speaker believes in a theory called the disposable soma, suggesting that our bodies aim to grow fast and reproduce fast, but this comes at the expense of building a long-lasting body. [Source: Document(page_content="00:14:50.61: it's a trade-off...")]
15. The speaker believes that limiting calories, carbs, and protein while ramping up on beneficial molecules could potentially improve quality of life and extend length of life. [Source: Document(page_content="00:15:30.43: limiting your amino acids but you're...")]