Alzheimer's and the Brain - Summary

Summary

The video by Vsauce, narrated by Michael Stevens, is an exploration of the human brain and its fascinating intricacies. The video begins with a demonstration of how quickly the hand moves, suggesting that the brain is a powerful and complex organ.

Stevens discusses the concept of memory, emphasizing that it is not a physical entity but a physical record of events or ideas. He mentions that before the invention of writing, humans relied on biological storage memories, essentially the knowledge and experiences of the oldest individuals in a group.

The video then transitions into a discussion about Alzheimer's disease, a neurodegenerative disorder that affects memory and cognitive abilities. Stevens explains how Alzheimer's is associated with the accumulation of plaques and tangles in the brain, which are caused by the protein amyloid precursor protein. He also mentions that the disease is more likely to affect older individuals.

The video then delves into the structure of the brain, explaining that the cerebrum, the largest part of the brain, is responsible for language, thought, abstract thinking, and consciousness. Stevens explains that the cerebrum is surrounded by a layer of gray matter and white matter, which are connected by axons that send messages between different parts of the brain.

Stevens also discusses the concept of connections in the brain, explaining that when neurons fire together, they form stronger bonds and become more likely to fire together again. This is how memory works, according to the video's narration.

The video concludes with a discussion on how to protect the brain and improve overall cognitive health. Stevens suggests activities such as physical activity, maintaining a heart-healthy diet, learning a second language, socializing, and engaging in intellectual activities to maintain brain health.

In the end, the video emphasizes the importance of continued research into the brain and the need for support for those affected by neurodegenerative diseases like Alzheimer's. The narrator also mentions that Vsauce has supported the Alzheimer's Association and encourages viewers to donate to this cause.

Facts

1. The speaker, Vsauce Michael, invites the audience to observe their hand's motion, which completes a trip around twice a day.
2. The hand's motion is slow and unnoticeable, but it represents a significant distance if compared to the Milky Way's size.
3. Before the invention of writing, humans relied on biological storage memories, with old people acting as libraries of experiences and thoughts.
4. Aeschylus famously said that memory is the mother of wisdom, but like all storage formats, individuals don't last forever.
5. Alzheimer's is a disease associated with a decline in cognitive skills, used to perform everyday activities.
6. Alzheimer's is not a part of normal aging symptoms, but includes a decrease in the ability to think and remember, confusion about time and place, and new difficulties speaking and writing.
7. Changes in mood and personality also occur in Alzheimer's patients.
8. Alzheimer's has grown from 2000 to 2013, despite other health challenges.
9. The brain is very wrinkly, allowing more cerebral cortex to fit into a smaller container.
10. Memories appear to be more about connections, relationships, and patterns formed by connected neurons.
11. When neurons fire together again and rehearse their connections, bonds become stronger and they become more likely to fire together again.
12. Brain cells and their connections can be damaged, blocked, compromised, or killed, hampering the formation of new memories.
13. Alzheimer's disease is associated with the plaques in the brain and another protein-related anomaly, tangles.
14. Factors associated with an increased risk for Alzheimer's disease include physical activity, a heart-healthy diet, learning a second language later in life, being social, frequently interacting with people, protecting your head, and intellectual activities like crossword puzzles, playing instruments, reading board games, and education.
15. The brain is still a scientific frontier, and we know more about the orbital mechanics of distant binary stars than we do about the very mechanisms we use to know about them in the first place.
16. Terry Pratchett famously said that the sword that will defeat Alzheimer's is probably made of gold.